San Francisco 49ers - NFL Schedule for 2025
| Date | Opponent | Game | Result | Score | ATS | Spread | OU | Total |
|---|---|---|---|---|---|---|---|---|
| Aug 9, 2025 | vs Denver | PRE | ||||||
| Aug 16, 2025 | @ Las Vegas | PRE | ||||||
| Aug 23, 2025 | vs LA Chargers | PRE | ||||||
| Sep 7, 2025 | @ Seattle | REG | ||||||
| Sep 14, 2025 | @ New Orleans | REG | ||||||
| Sep 21, 2025 | vs Arizona | REG | ||||||
| Sep 28, 2025 | vs Jacksonville | REG | ||||||
| Oct 2, 2025 | @ LA Rams | REG | ||||||
| Oct 12, 2025 | @ Tampa Bay | REG | ||||||
| Oct 19, 2025 | vs Atlanta | REG | ||||||
| Oct 26, 2025 | @ Houston | REG | ||||||
| Nov 2, 2025 | @ NY Giants | REG | ||||||
| Nov 9, 2025 | vs LA Rams | REG | ||||||
| Nov 16, 2025 | @ Arizona | REG | ||||||
| Nov 24, 2025 | vs Carolina | REG | ||||||
| Nov 30, 2025 | @ Cleveland | REG | ||||||
| Dec 14, 2025 | vs Tennessee | REG | ||||||
| Dec 22, 2025 | @ Indianapolis | REG | ||||||
| Dec 28, 2025 | vs Chicago | REG | ||||||
| Jan 4, 2026 | vs Seattle | REG |
